The drug pyrazinamide is part of the standard therapy, which consists of rifampicin, isoniazid, pyrazinamide and ethambutol.

Pyrazinamide is administered at the beginning of the 6-month standard therapy in the initial phase over 2 months. The dosage depends on body weight. If possible, it should be taken together with the other medications at least 30 minutes before breakfast, as this is the most effective way. If this results in poor tolerance, it can also be taken after a light breakfast or in the evening.

A possible side effect is an allergic reaction with skin rash and itching. The medication can damage the liver, so blood values must be checked at regular intervals. Alcohol should be avoided for the duration of therapy to avoid putting unnecessary additional strain on the liver. Other side effects can include nausea, vomiting, joint or muscle pain and facial flushing. The uric acid level is often shown as elevated in the laboratory. As a rule, this change does not pose a health risk and only needs to be treated if it is accompanied by symptoms such as gout.

The treating physicians should be informed of any side effects so that they can react to them and possibly adjust the therapy.

If a medication in the standard therapy does not work or is intolerable, the composition and duration of the therapy can be changed. If the tablets are not taken regularly, the therapy may fail. The bacteria then begin to multiply again and can become resistant to the medication taken. This can lead to more complicated and longer treatment with poorer chances of recovery.